Design and evaluation of sustained release bilayer tablets of propranolol hydrochloride
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چکیده
منابع مشابه
Design and evaluation of sustained release bilayer tablets of propranolol hydrochloride.
The objective of the present research was to develop a bilayer tablet of propranolol hydrochloride using superdisintegrant sodium starch glycolate for the fast release layer and water immiscible polymers such as ethylcellulose, Eudragit RLPO and Eudragit RSPO for the sustaining layer. In vitro dissolution studies were carried out in a USP 24 apparatus I. The formulations gave an initial burst e...
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The purpose of this study was to develop a new monolithic matrix tablet to completely deliver glipizide in a zero order manner over a sustained period. Two approaches were examined using drug in a formulation that contain polymer like hydroxylpropyl methyl-cellulose K 100 (HPMCK) and Eudragit L 100. The granules were prepared by wet granulation method and thereby formulated as F-1, F-2. F...
متن کاملDesign and evaluation of sustained release bilayer tablets of propranolol hydrochloride CHINAM NIRANJAN PATRA* ARETHI BHARANI KUMAR HEMANT KUMAR PANDIT SATYA PRAKASH SINGH MEDURI VIMALA DEVI
used in the treatment of hypertension, angina pectoris, pheochromocytoma and cardiac arrhythmias (1). Because of its relatively short plasma half-life, patients are routinely asked to take propranolol hydrochloride in divided daily doses, once every 6 to 8 h. Such frequent drug administration may reduce patient compliance and therapeutic efficacy (2). In recent years, slow or sustained release ...
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PURPOSE The aim of the present study was to improve the bioavailability of itopride (ITO) and sustain its action by formulating as a floating dosage form. MATERIALS AND METHODS Sustained-release floating tablets of ITO hydrochloride (HCl) were prepared by direct compression using different hydrocolloid polymers such as hydroxypropyl methylcellulose and ethylcellulose and/or methacrylic acid p...
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This study was performed to design bilayer regioselective floating tablets of atenolol and lovastatin to give immediate release of lovastatin and sustained release of atenolol. Bilayer floating tablets comprised two layers, i.e immediate release and controlled release layers. The immediate release layer comprised sodium starch glycollate as a super disintegrant and the sustained release layer c...
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ژورنال
عنوان ژورنال: Acta Pharmaceutica
سال: 2007
ISSN: 1846-9558,1330-0075
DOI: 10.2478/v10007-007-0038-0